Malignant Peritoneal Mesothelioma: A Comprehensive Guide


Welcome to our guide on malignant peritoneal mesothelioma. This rare form of cancer affects the lining of the abdomen and can be difficult to diagnose and treat. In this article, we will provide a thorough explanation of malignant peritoneal mesothelioma, including its causes, symptoms, diagnosis, and treatment options. We hope that this guide will help those who are dealing with this disease, as well as their loved ones and caregivers.

What is Malignant Peritoneal Mesothelioma?

Malignant peritoneal mesothelioma is a type of cancer that affects the peritoneum, which is the lining of the abdomen. The cancer is characterized by the growth of malignant cells in the peritoneum, which can spread to other organs and tissues in the body. The cancer is caused by exposure to asbestos, which is a naturally occurring mineral that was once widely used in construction and other industries. Asbestos fibers can be inhaled or ingested, and they can become lodged in the body, leading to the development of mesothelioma.

What are the Symptoms of Malignant Peritoneal Mesothelioma?

The symptoms of malignant peritoneal mesothelioma can be vague and non-specific, which can make it difficult to diagnose the disease. Common symptoms of the disease include:

Symptom Description
Abdominal Pain Pain in the abdomen that may be severe or mild
Ascites Excess fluid in the abdomen that causes swelling and discomfort
Anorexia Loss of appetite and weight loss
Bowel Obstruction Difficulty passing stools or gas
Jaundice Yellowing of the skin and eyes
Fever Low-grade fever that persists for weeks or months
Fatigue Extreme tiredness and weakness

How is Malignant Peritoneal Mesothelioma Diagnosed?

The diagnosis of malignant peritoneal mesothelioma can be challenging, as the symptoms of the disease can be similar to those of other conditions. Diagnosis begins with a thorough medical history and physical examination. Additional tests that may be used to diagnose the disease include:

Imaging Tests:

Imaging tests such as CT scans, MRIs, and X-rays can be used to examine the abdomen and look for signs of cancer.


A biopsy involves the removal of a sample of tissue from the peritoneum for examination under a microscope. This is the most definitive way to diagnose malignant peritoneal mesothelioma.

Blood Tests:

Blood tests may be used to look for markers that are associated with malignant peritoneal mesothelioma, such as mesothelin.

What are the Treatment Options for Malignant Peritoneal Mesothelioma?

The choice of treatment for malignant peritoneal mesothelioma depends on various factors, including the stage of the cancer, the patient’s age and health, and the extent of the cancer. The treatment options for malignant peritoneal mesothelioma include:


Surgery may be used to remove the cancerous tissue from the peritoneum. This may involve the removal of a portion of the peritoneum, as well as any other affected organs or tissues. In some cases, surgery may be curative, but in others, it may be palliative.


Chemotherapy involves the use of drugs to kill cancer cells. This may be given before or after surgery, or it may be used as the primary treatment for malignant peritoneal mesothelioma.

Radiation Therapy:

Radiation therapy involves the use of high-energy radiation to kill cancer cells. It may be used in combination with surgery or chemotherapy.

Experimental Therapies:

There are various experimental therapies that may be used to treat malignant peritoneal mesothelioma, including immunotherapy and gene therapy. These treatments are still in the early stages of development and may not be widely available.


1. Can malignant peritoneal mesothelioma be prevented?

Malignant peritoneal mesothelioma can be prevented by avoiding exposure to asbestos. It is also important to follow workplace safety guidelines if you work with asbestos-containing materials.

2. What are the risk factors for malignant peritoneal mesothelioma?

The primary risk factor for malignant peritoneal mesothelioma is exposure to asbestos. Other risk factors include age, gender, and a family history of mesothelioma.

3. Can malignant peritoneal mesothelioma be cured?

There is currently no cure for malignant peritoneal mesothelioma, but treatment options can help to manage symptoms and prolong survival.

4. How common is malignant peritoneal mesothelioma?

Malignant peritoneal mesothelioma is a rare form of cancer, accounting for less than 20% of all mesothelioma cases.

5. What are the long-term effects of malignant peritoneal mesothelioma?

The long-term effects of malignant peritoneal mesothelioma can vary depending on the stage of the cancer and the treatment received. Some people may experience side effects from treatment, such as fatigue, nausea, and hair loss. In some cases, the cancer may recur after treatment.

6. How is malignant peritoneal mesothelioma different from other types of mesothelioma?

Malignant peritoneal mesothelioma is a type of mesothelioma that affects the peritoneum, while other types of mesothelioma affect the pleura (the lining of the lungs) or the pericardium (the lining of the heart).

7. What is the prognosis for malignant peritoneal mesothelioma?

The prognosis for malignant peritoneal mesothelioma is generally poor, with a median survival rate of less than two years. However, some people with the disease may live longer with proper treatment and management.


We hope that this guide has provided helpful information about malignant peritoneal mesothelioma. While the disease can be challenging to diagnose and treat, there are various options available that can help manage symptoms and prolong survival. If you or a loved one has been diagnosed with malignant peritoneal mesothelioma, it is essential to work closely with your healthcare team to develop a treatment plan that meets your individual needs.

Take Action:

If you suspect that you may have been exposed to asbestos, it is important to speak with your doctor about your risk for mesothelioma. Early detection can lead to better treatment outcomes and improved quality of life.


This guide is for informational purposes only and should not be used as a substitute for professional medical advice. Always consult with your healthcare provider if you have any questions or concerns about your health or the treatment of malignant peritoneal mesothelioma.