Mesothelioma Treatment Options: Finding the Right Path for You

Welcome to our comprehensive guide on mesothelioma treatment options. This form of cancer is a rare but deadly disease that affects the lining of the lungs, heart, or abdomen. It is primarily caused by exposure to asbestos fibers and is often diagnosed at an advanced stage. Mesothelioma treatment options vary depending on the stage and location of the cancer, as well as the patient’s overall health. In this guide, we will explore the different types of treatments available and help you navigate through the difficult decisions you may face. Let’s get started.

Understanding Mesothelioma

Mesothelioma is a challenging disease to diagnose and treat due to its rarity and similarity to other illnesses. It can take decades for symptoms to appear, making early detection difficult. Mesothelioma is most commonly found in patients who have been exposed to asbestos fibers, which were commonly used in construction, manufacturing, and other industrial settings. Once inhaled, these fibers can embed in the lungs, heart, or abdomen, causing inflammation and eventually leading to mesothelioma. There are four primary types of mesothelioma: pleural, peritoneal, pericardial, and testicular. Each type affects different parts of the body and requires different treatment strategies.

Pleural Mesothelioma

Pleural mesothelioma is the most common type, accounting for about 75% of cases. It affects the lining of the lungs and typically presents with symptoms such as chest pain, cough, and shortness of breath. Treatments for pleural mesothelioma include surgery, radiation therapy, chemotherapy, immunotherapy, and multimodal therapy, a combination of two or more treatments.

Peritoneal Mesothelioma

Peritoneal mesothelioma affects the lining of the abdomen and accounts for about 20% of cases. Its symptoms include abdominal pain, swelling, and weight loss. It is often treated with surgery, chemotherapy, or a combination of both.

Pericardial Mesothelioma

Pericardial mesothelioma is a rare type of mesothelioma that affects the lining of the heart. It can cause chest pain, shortness of breath, and heart palpitations. Because the heart is a vital organ, treatments for pericardial mesothelioma are challenging, and the focus is on symptom management. Palliative care, surgery, chemotherapy, and radiation therapy may be used to alleviate symptoms.

Testicular Mesothelioma

Testicular mesothelioma is the rarest form of mesothelioma, accounting for less than 1% of cases. It affects the lining of the testicles and can cause swelling, pain, and lumps in the testicles. Treatment for testicular mesothelioma includes surgery and chemotherapy.

Mesothelioma Treatment Options

Mesothelioma treatment options depend on several factors, including the type of cancer, the stage of the disease, and the patient’s overall health. Let’s take a closer look at the different types of treatments available.


Surgery is a common treatment for mesothelioma and can be used to remove tumors or affected tissues. It is typically used in early-stage mesothelioma when the cancer has not spread. There are several types of surgical procedures used in mesothelioma treatment, including:

Surgical Procedure Description
Pleurectomy/decortication (P/D) Removes the affected lining of the lungs and chest wall
Extrapleural pneumonectomy (EPP) Removes the entire lung, affected lining of the chest wall, and nearby tissues
Cytoreduction with heated intraperitoneal chemotherapy (HIPEC) Removes the affected lining of the abdomen and delivers a heated chemotherapy solution to the abdominal cavity

Radiation Therapy

Radiation therapy involves using high-energy rays to kill cancer cells. It is often used in combination with surgery or chemotherapy. There are two types of radiation therapy: external beam radiation therapy and internal radiation therapy. External beam radiation therapy uses a machine outside the body to deliver radiation to the cancer. Internal radiation therapy, also known as brachytherapy, involves placing a radioactive source directly into or near the cancer.


Chemotherapy is a systemic treatment that uses drugs to kill cancer cells throughout the body. It can be administered orally or intravenously and is often used in combination with surgery or radiation therapy. There are several different chemotherapy drugs used in mesothelioma treatment, including pemetrexed and cisplatin.


Immunotherapy is a relatively new type of cancer treatment that works by boosting the body’s immune system to fight cancer. It is typically used when other treatments have not been effective. The most common type of immunotherapy used in mesothelioma treatment is checkpoint inhibitors, which help the immune system recognize and attack cancer cells.

Multimodal Therapy

Multimodal therapy involves using two or more treatment types in combination to achieve the best results. For example, surgery may be used to remove tumors, followed by chemotherapy or radiation therapy to kill any remaining cancer cells. Multimodal therapy may be an option for patients with early-stage mesothelioma who are healthy enough to undergo multiple treatments.

FAQs about Mesothelioma Treatment Options

1. What are the side effects of mesothelioma treatment?

The side effects of mesothelioma treatment can vary depending on the type of treatment used. Common side effects include fatigue, nausea, hair loss, and decreased appetite. Speak with your doctor about the potential side effects of your specific treatment plan.

2. Can mesothelioma be cured?

There is currently no cure for mesothelioma, but treatment options can help improve symptoms and prolong survival.

3. How long does mesothelioma treatment last?

The duration of mesothelioma treatment can vary depending on the type of cancer and the stage of the disease. Treatment may last for several months to a year or more.

4. Will I be able to work during mesothelioma treatment?

This depends on the type of treatment you receive and your overall health. Some patients are able to continue working during treatment, while others may need to take time off. Speak with your doctor about your specific situation.

5. Is there financial assistance available for mesothelioma treatment?

There are several resources available to help cover the cost of mesothelioma treatment, including government programs, private insurance, and mesothelioma-specific foundations.

6. Can mesothelioma recur after treatment?

Yes, mesothelioma can recur after treatment. Regular follow-up appointments and imaging scans are essential in monitoring for any signs of recurrence.

7. What is the success rate of mesothelioma treatment?

The success rate of mesothelioma treatment can vary depending on the type and stage of the disease, as well as the patient’s overall health. Clinical trials have shown that some treatment options can help prolong survival and improve quality of life.

8. Are there any experimental treatments for mesothelioma?

Yes, there are several experimental treatments for mesothelioma being studied, including gene therapy, targeted therapy, and viral therapy. Speak with your doctor about any clinical trials that may be available to you.

9. How can I prepare for mesothelioma treatment?

Preparing for mesothelioma treatment involves understanding the treatment options, potential side effects, and any lifestyle changes that may be required. Be sure to ask your doctor any questions you may have and seek support from loved ones or support groups.

10. Can alternative therapies be used in conjunction with mesothelioma treatment?

While alternative therapies such as acupuncture or herbal supplements may be used to manage symptoms, they should not be used as a substitute for conventional mesothelioma treatment. Always speak with your doctor before trying any alternative therapies.

11. Can mesothelioma treatment affect my fertility?

Chemotherapy and radiation therapy can affect fertility in both men and women. Speak with your doctor about your options for preserving fertility before beginning treatment.

12. Can mesothelioma treatment be customized to my needs?

Yes, mesothelioma treatment can be tailored to your specific needs based on a variety of factors, including your age, overall health, and the stage and location of the cancer.

13. What is the best mesothelioma treatment option for me?

The best mesothelioma treatment option for you will depend on several factors, including the type and stage of the cancer, your overall health, and your personal preferences. Work closely with your medical team to identify the treatment plan that is right for you.


Mesothelioma is a challenging disease, but there are treatment options available to help manage symptoms and prolong survival. From surgery to chemotherapy to immunotherapy, there are several different approaches to mesothelioma treatment that can be customized to your needs. If you have been diagnosed with mesothelioma, remember to ask questions, seek support from loved ones, and work closely with your medical team to develop a treatment plan that is right for you. With the right treatment and support, it is possible to live a fulfilling life with mesothelioma.


The information provided in this article is for educational purposes only and is not intended to serve as medical advice or a substitute for professional medical care. Always consult with your doctor or medical team about your specific health needs and mesothelioma treatment options.