Mesothelioma Trials: Fighting Against A Rare and Deadly Cancer

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Welcome to our comprehensive guide to mesothelioma trials. Mesothelioma is a rare and aggressive form of cancer that occurs in the lining of the lungs, abdomen, or heart. It is typically caused by exposure to asbestos, a toxic mineral once widely used in various industries. Unfortunately, the symptoms of mesothelioma often do not manifest until the cancer has reached an advanced stage, making it difficult to treat.

Researchers are continually searching for new and innovative treatments to improve the prognosis of mesothelioma patients. Clinical trials are a critical avenue for discovering these treatments, as they allow researchers to test the effectiveness of new drugs, therapies, and procedures. This guide provides an in-depth look at mesothelioma trials, including what they are, how they work, and the latest breakthroughs in mesothelioma research.

At the end of this guide, we hope to leave you with a deeper understanding of mesothelioma trials and the hope they bring to those affected by this devastating disease.

What Are Mesothelioma Trials?

Mesothelioma trials are research studies that evaluate new treatments, drugs, or therapies for mesothelioma. These trials aim to determine the effectiveness and safety of these new treatments and determine whether they can be used as part of standard mesothelioma treatment protocols.

Every mesothelioma clinical trial follows a strict set of guidelines and protocols to ensure the safety and well-being of its participants. These protocols outline the eligibility criteria, treatment plans, and monitoring procedures for the trial.

There are four phases of clinical trials:

Phase Description
Phase I Tests the safety of a new drug or treatment on a small group of people.
Phase II Expands the trial to a larger group of people to determine the effectiveness of the drug or treatment.
Phase III Compares the new drug or treatment to the current standard treatment to determine which is more effective.
Phase IV Monitors the long-term effects of the drug or treatment after it has been approved by the FDA.

Why Are Mesothelioma Trials Important?

Mesothelioma trials are essential for several reasons:

  • They help to identify new and effective treatments for mesothelioma.
  • They provide patients with access to cutting-edge drugs and therapies that may not be available outside of clinical trials.
  • They advance our understanding of mesothelioma and the underlying mechanisms of the disease.
  • They provide hope for mesothelioma patients and their families by offering new treatment options and the possibility of improved outcomes.

Latest Breakthroughs in Mesothelioma Trials

Recent years have seen significant breakthroughs in mesothelioma research, with several promising new treatments in development. Here are some of the latest breakthroughs:


Immunotherapy is a type of treatment that uses the body’s immune system to fight cancer. One promising type of immunotherapy for mesothelioma is called checkpoint inhibitor therapy. This treatment blocks the proteins that allow cancer cells to hide from the immune system, allowing the body to recognize and attack the cancer cells more effectively.

Gene Therapy

Gene therapy is a type of treatment that involves altering the genes inside cancer cells to stop them from growing and spreading. In mesothelioma trials, researchers are using a type of gene therapy that involves inserting a virus into the cancer cells, triggering an immune response that attacks the cancer.

Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

HIPEC is a type of treatment that involves heating chemotherapy drugs and then delivering them directly to the abdomen. This treatment has shown promising results in mesothelioma patients, with some studies reporting increased survival rates.

Mesothelioma Trials: What You Need to Know

Types of Mesothelioma Trials

There are several types of mesothelioma trials:

Treatment Trials

Treatment trials test new drugs or treatments for mesothelioma. These trials can be for patients at all stages of the disease and may test the effectiveness of chemotherapy, surgery, radiation, or a combination of these treatments.

Prevention Trials

Prevention trials aim to identify ways to prevent mesothelioma from developing. These trials may focus on high-risk populations, such as those who have been exposed to asbestos in the workplace.

Diagnostic Trials

Diagnostic trials aim to improve the accuracy and speed of mesothelioma diagnosis. These trials may test new imaging techniques or biomarkers that can detect mesothelioma at an earlier stage.

Symptom Management Trials

Symptom management trials aim to improve the quality of life for mesothelioma patients by relieving symptoms such as pain or shortness of breath. These trials may test new medications, therapies, or strategies for managing symptoms.

Who Can Participate in Mesothelioma Trials?

Each mesothelioma trial has its own eligibility criteria, based on factors such as age, stage of disease, and previous treatments. Generally, mesothelioma trials are open to patients who:

  • Have been diagnosed with mesothelioma
  • Meet the specific eligibility criteria for the trial
  • Are willing to undergo the treatment and follow the trial protocols

How to Find Mesothelioma Trials

Several resources are available to help individuals find mesothelioma trials:

National Cancer Institute

The National Cancer Institute (NCI) maintains a comprehensive database of ongoing clinical trials, including those for mesothelioma. Individuals can search the database by diagnosis, treatment type, and location.

Mesothelioma Applied Research Foundation

The Mesothelioma Applied Research Foundation is a nonprofit organization dedicated to funding research and providing support to mesothelioma patients and their families. The organization maintains a searchable database of mesothelioma clinical trials.

Cancer Centers and Hospitals

Many cancer centers and hospitals offer mesothelioma clinical trials. Individuals can contact these institutions directly to inquire about ongoing trials.

What Are the Benefits and Risks of Participating in Mesothelioma Trials?

Participating in a mesothelioma trial can offer several benefits:

  • Access to cutting-edge treatments
  • The possibility of improved outcomes
  • The opportunity to contribute to mesothelioma research and help future patients

However, there are also potential risks involved in participating in clinical trials:

  • Possible side effects or complications from the treatment
  • The treatment may not be effective
  • The trial may require more time and commitment than standard treatments

What Happens During a Mesothelioma Trial?

Every mesothelioma trial will have its own set of protocols and procedures, but here is a general overview of what to expect:


Before being accepted into a trial, individuals will need to undergo screening to determine if they meet the eligibility criteria.

Treatment Administration

Individuals who are accepted into the trial will receive the treatment according to the trial protocols. Depending on the trial, this may involve medications, chemotherapy, radiation, or surgery.


Throughout the trial, individuals will be closely monitored to track their response to treatment, any side effects, and their overall well-being.

What Happens After a Mesothelioma Trial?

After a mesothelioma trial is complete, researchers will analyze the data to determine the effectiveness and safety of the treatment. If the treatment is found to be effective and safe, it may become part of standard mesothelioma treatment protocols. If not, researchers will continue searching for new treatments and therapies.

Mesothelioma Trials: Frequently Asked Questions

1. How long does a mesothelioma trial last?

The duration of a mesothelioma trial can vary depending on the type of trial, the treatment being tested, and other factors. Some trials may last for several months, while others may last several years.

2. Can I receive standard mesothelioma treatments while participating in a trial?

It depends on the trial. Some trials may allow participants to receive standard treatments in addition to the trial treatment, while others may require participants to forego standard treatments during the trial.

3. Will I be compensated for participating in a mesothelioma trial?

It depends on the trial. Some trials may offer compensation for travel expenses or other costs associated with participating in the trial. However, compensation is not guaranteed, and each trial will have its own policies regarding compensation.

4. Can I leave a mesothelioma trial once I’ve started?

Yes, individuals are free to leave a mesothelioma trial at any time, for any reason. However, it’s essential to discuss this decision with your doctor before making any changes to your treatment plan.

5. What are the eligibility criteria for mesothelioma trials?

The eligibility criteria for mesothelioma trials vary depending on the trial and its protocol. Factors that may influence eligibility include age, stage of disease, previous treatments, and overall health.

6. Is there a cost to participate in mesothelioma trials?

It depends on the trial. Some trials may cover the costs of treatment and associated medical care, while others may require participants to cover some of the costs themselves or through their insurance.

7. Will I receive a placebo during a mesothelioma trial?

It depends on the trial. Some trials may use a placebo, while others may not. Your doctor will explain the trial protocol and whether a placebo is being used.

8. Can I participate in a mesothelioma trial if I live outside the US?

Yes, individuals from outside the US can participate in mesothelioma clinical trials. However, it’s essential to review the protocol and any potential travel requirements before participating.

9. Can family members participate in mesothelioma trials?

No, mesothelioma trials are only open to individuals who have been diagnosed with mesothelioma and meet the eligibility criteria for the trial.

10. What happens if I experience side effects during a mesothelioma trial?

If you experience side effects during a mesothelioma trial, your medical team will monitor you closely and may adjust your treatment plan to manage the symptoms. You may also be required to report any side effects to the research team so that they can be properly documented.

11. Can I continue working while participating in a mesothelioma trial?

It depends on the trial and your overall health. Some trials may allow participants to continue working, while others may prohibit it due to potential health risks or the demands of the trial protocol.

12. Can I participate in more than one mesothelioma trial?

No, individuals are generally not allowed to participate in more than one mesothelioma trial at a time. However, it may be possible to participate in a different trial after completing one trial, depending on the trial protocols and eligibility criteria.

13. What happens if the mesothelioma trial treatment is not effective?

If the mesothelioma trial treatment is not effective, individuals will be removed from the trial and may be offered other treatment options.


Mesothelioma is a rare and deadly cancer that requires innovative and effective treatments to improve patient outcomes. Mesothelioma trials offer hope for those affected by the disease, by providing access to cutting-edge therapies and advancing our understanding of the disease. While mesothelioma trials are not without risks, they offer the possibility of improved outcomes, and the opportunity to contribute to mesothelioma research.

If you or a loved one has been diagnosed with mesothelioma, we urge you to speak with your doctor about whether a mesothelioma trial may be a viable treatment option. Together, we can continue the fight against this devastating disease.


This guide is for informational purposes only and is not intended to provide medical advice or replace the advice of a qualified healthcare provider. It is essential to speak with your doctor about any questions or concerns you may have regarding mesothelioma treatment options. We do not guarantee the accuracy or completeness of the information in this guide, and we are not responsible for any errors or omissions.